SMOOTH (Skin & Mucosal Microbes Omics-based Total Health) Laboratory is an interdisciplinary research facility integrating skin microbiome big data with artificial intelligence, affiliated with Southern Medical University.

The team focuses on multiple domains including skin microbiome and regeneration, barrier repair, wound healing, dermatological diseases, skin-flexible materials, and microbiome big data analytics. We have established multiple large-scale clinical cohorts, curated tens of thousands of clinical raw datasets (totaling ~600TB), and maintain four dedicated servers. Our infrastructure includes a full suite of microbiome research equipment and technologies, supported by specialized bioinformatics personnel. Currently, several major projects are ongoing. Since its establishment three years ago, the team has published numerous first-author papers in high-impact journals and their sub-journals. We particularly welcome candidates with strong backgrounds in big data analysis and microbiome research to join our team!

Phytic Acid Improves the Skin Barrier Function in Murine Models of Atopic Dermatitis Through Skin Microbiota-Derived Indole-3-Propionic Acid​
Piao Wang, Lan Yang, Lu Chen, Xinyu Huang, Zhen Lin, Yue Li, Caiyu Qi, Tianren Xu, Jianglin Zhang, Min Qi, Biao Cheng, Junjie Wang, Zhiqi Hu, Gaofeng Wang, Allergy (2025).
Published 09 Jul 2025
Immunotyping the Tumor Microenvironment Reveals Molecular Heterogeneity for Personalized Immunotherapy in Cancer​
Dongqiang Zeng, Yunfang Yu, Wenjun Qiu, Qiyun Ou, Qianqian Mao, Luyang Jiang, Jianhua Wu, Jiani Wu, Huiyan Luo, Peng Luo, Wenchao Gu, Na Huang, Siting Zheng, Shaowei Li, Yonghong Lai, Xiatong Huang, Yiran Fang, Qiongzhi Zhao, Rui Zhou, Huiying Sun, Wei Zhang, Jianping Bin, Yulin Liao, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Min Shi, Wangjun Liao​, Advanced Science 12 (15) :e2417593​​ (2025).
Published 28 May 2025
The Role of Skin-Gut-Lung Microbiome in Allergic Diseases
Lan Yang, Zhen Lin, Ting Gao, Piao Wang, Gaofeng Wang, Journal of Allergy and Clinical Immunology: In Practice 13 (5) :S2213-2198(25)00410-6 (2025).
Published 02 May 2025